CANCER CURES #1: THE SOURSOP

http://www.fda.gov/ohrms/dockets/dailys/02/Aug02/080102/02N-0209-EC-290.html and http://www.soursopgraviola.com/ and http://www.graviolaleaves.com/ and

http://www.facebook.com/note.php?note_id=97858284832&id=187840790496&ref=mf and http://www.facebook.com/notes/health-discovery/cancer-cure-discovered-guyabano-the-soupsop-fruit/126619070704651

Two chemicals extracted from Graviola seeds showed "selective cytotoxicity comparable with Adriamycin" for breast and colon cancer cells. The chemicals targeted and killed malignant breast and colon cells in a test tube--comparable to the commonly used chemotherapy drug Adriamycin.

STUDY BY  M H Woo, S O Chung, D H Kim Department of Pharmacy, College of Pharmacy, Catholic University of Taegu-Hyosung, Kyongsan, South Korea.

QUOTE:  Two new bioactive mono-tetrahydrofuran (THF) gamma-lactone acetogenins, asitrilobins C (1) and D (2), were isolated from the seeds of Asimina triloba (Annonaceae) by directing the fractionation with brine shrimp lethality. Compounds 1 and 2 have a relative stereochemical relationship of threo/trans/threo across the mono-THF ring with its two flanking hydroxyls. Their structures were established on the basis of chemical and spectral evidence. Compounds 1 and 2 showed selective cytotoxicity comparable with adriamycin for the breast carcinoma (MCF-7) and the colon adenocarcinoma (HT-29) cell lines.

Another study, published in the Journal of Natural Products, showed that Graviola is not only comparable to Adriamycin--but dramatically outperforms it in laboratory tests. Results showed that one chemical found in Graviola selectively kill red colon cancer cells at "10,000 times the potency of Adriamycin."

STUDY BY Rieser MJ, Gu ZM, Fang XP, Zeng L, Wood KV, McLaughlin JL.

AgrEvo Research Center, Pikeville, North Carolina 27863, USA.

QUOTE:  Bioactivity-directed fractionation of the seeds of Annona muricata L. (Annonaceae) resulted in the isolation of five new compounds: cis-annonacin (1), cis-annonacin-10-one (2), cis-goniothalamicin (3), arianacin (4), and javoricin (5). Three of these (1-3) are among the first cis mono-tetrahydrofuran ring acetogenins to be reported. NMR analyses of published model synthetic compounds, prepared cyclized formal acetals, and prepared Mosher ester derivatives permitted the determinations of absolute stereochemistries. Bioassays of the pure compounds, in the brine shrimp test, for the inhibition of crown gall tumors, and in a panel of human solid tumor cell lines for cytotoxicity, evaluated relative potencies. Compound 1 was selectively cytotoxic to colon adenocarcinoma cells (HT-29) in which it was 10,000 times the potency of adriamycin.

Graviola selectively targets cancer cells leaving healthy cells untouched. Chemotherapy indiscriminately seeks and destroys all actively reproducing cells - even normal, healthy ones. Other promising and ongoing research at Purdue University is supported by a grant from the National Cancer Institute. Purdue researchers recently found that leaves from the Graviola tree killed cancer cells "among six human-cell lines" and were especially effective against prostate and pancreatic cancer cells.  In a separate study, Purdue researchers showed that extracts from the Graviola leaves are extremely effective in isolating and killing lung cancer cells.

CITATIONS:

1. Unpublished data, National Cancer Institute. Anon: Nat Cancer 1st Central Files

( 1976) from Napralert Files, University of Illinois, 1995
2. Bioorg Med Chem 8(1):285-90, 2000
3. J Nat Prod 59(2):100-108, 1996
4. Phytochemistry 49(2):565-7 1, 1998
5. J. Nat Prod 58(6):902-908, 1995